Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

SIGNATURE: a single-particle selection system for molecular electron microscopy.

SIGNATURE is a particle selection system for molecular electron microscopy. It applies a hierarchical screening procedure to identify molecular particles in EM micrographs. The user interface of the program provides versatile functions to facilitate image data visualization, particle annotation and particle quality inspection. The system design emphasizes both functionality and usability. This ...

متن کامل

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design

Recent developments in electron microscopy (EM) have led to a step change in our ability to solve the structures of previously intractable systems, especially membrane proteins and large protein complexes. This has provided new opportunities in the field of structure-based drug design, with a number of high-profile publications resolving the binding sites of small molecules and peptide inhibito...

متن کامل

Comparison of Aerobic Sporadic Bacilli Structure with Electron Microscopy

I. The existence of differences and similarities in the sur- 4. face features not only of different organisms or groups but also within given species has been demonstrated by a variety of techniques. 2. The different reactions of various organisms to the Gram stain might well be taken as one piece of evidence, the use of the electron microscop and associated prepa­rative techniques (includi...

متن کامل

High-Resolution Single-Molecule Structure Revealed by Electron Microscopy and Individual Particle Electron Tomography

A single, unique structure of protein determined by X-ray crystal is often used for studies in structure–function relationships. However, the protein is naturally dynamic and fluctuation in solution, the single unique structure is insufficient to illuminate the dynamic character and “personalities” [1,2]. Other than a theoretical calculation approach, such as molecular dynamics simulation is ab...

متن کامل

Advantages of CCD detectors for de novo three-dimensional structure determination in single-particle electron microscopy.

For three-dimensional (3D) structure determination of large macromolecular complexes, single-particle electron cryomicroscopy is considered the method of choice. Within this field, structure determination de novo, as opposed to refinement of known structures, still presents a major challenge, especially for macromolecules without point-group symmetry. This is primarily because of technical issu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2017

ISSN: 0021-9258

DOI: 10.1074/jbc.m117.789495